Responsibilities
Reseach group leader
Contact
Institute of Neuronal Cell Biology
Biedersteiner Str. 29
D-80802 Munich
Phone:
+49 (0)89 / 4140-3377
Email:
monika.leischner-brill@tum.de
Website:
https://web.med.tum.de/neuroscience/home/
Further Information
Keywords: axon, cytoskeleton, motor neuron disease, motor neuron, posttranslational modifications, microtubule
Research description: Neurons are highly compartimentalized cells, and some neurons possess long axons where neurotransmission occurs. The microtubule cytoskeleton is essential in maintenance of axonal homoeostasis, as it fulfills essentials functions, such as providing physical shape, and the basis for transport of organelles. Using motor axons as a model, we focus on alterations of the microtubule cytoskeleton and posttranslational modifications during disease and development. We combine quantitative immunostainings, with electron microscopy and live imaging of transgenics or virally injected mice.
Selected publications:
Neural labeling and manipulation by neonatal intraventricular viral injection. Wang M, Misgeld T, Brill MS# STAR Protoc. 2022 Jan 10;3(1):101081. doi: 10.1016/j.xpro.2021.101081
Completion of neuronal remodeling prompts myelination along developing motor axon branches. Wang M, Kleele T, Xiao Y, Plucinska G, Avramopoulos P , Engelhardt S, Markus H Schwab MH, Kneussel M, Czopka T, Sherman DL, Brophy PJ , Misgeld T, Brill MS# J Cell Biol. 2021 Apr 5;220(4):e201911114. doi: 10.1083/jcb.201911114
Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination. Brill MS*#, Kleele T*, Ruschkies L*, Wang M, Marahori N, Reuter M, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T#. #corresponding authors Neuron. 2016 Nov 23;92(4):845-856. doi: 10.1016/j.neuron.2016.09.049
Spatial constraints dictate glial territories at murine neuromuscular junctions. Brill MS, Lichtman JW, Thompson W, Zuo Y, Misgeld T. J Cell Biol. 2011 Oct 17;195(2):293-305. doi: 10.1083/jcb.201108005
Adult generation of glutamatergic olfactory neurons. Brill MS*, Ninkovic J*, Helps E*, Hodge RD*, Ozen I, Yang R, Lepier A, Gascon S, Szabo G, Ferenc E, Frotscher F, Berninger B, Parras C, Guillemot F, Hevner RF, Raineteau O, Götz M. Nat Neurosci. 2009 Dec;12(12):1524-33 doi: 10.1038/nn.2416