Responsibilities
Lab Head, Gene Center, Max von Pettenkofer-Institute of Virology
Contact
Gene Center
Feodor-Lynen Strasse 25
81377 Munich
Phone:
+49 (0)89 / 2180-76851
Fax:
+49 (0)89 / 2180-76899
Email:
conzelmann@genzentrum.lmu.de
Website:
http://www.conzelmann.genzentrum.lmu.de/karl-klaus-conzelmann/
Further Information
Research focus: Molecular biology of viruses from the order of Mononegavirales, mainly rabies virus and measles virus.
Key words: Neurotracing, rabies virus budding, interferon escape, measles, virus proteins, reverse genetics, negative-sense RNA virus, virus-host interplay, pathogenicity, biotechnological tools, live vaccines
Selected publications:
Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M. (2016) Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nat Commun. 7:13275.
Falkner S, Grade S, Dimou L, Conzelmann KK, Bonhoeffer T, Götz M, Hübener M. (2016) Transplanted embryonic neurons integrate into adult neocortical circuits. Nature. doi: 10.1038/nature20113.
Ghanem A, Conzelmann KK. ( 2016) G gene-deficient single-round rabies viruses for neuronal circuit analysis. Virus Res. 216:41-54.
Wertz A, Trenholm S, Yonehara K, Hillier D, Raics Z, Leinweber M, Szalay G, Ghanem A, Keller G, Rózsa B, Conzelmann KK, Roska B. (2015) Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules. Science 349(6243):70-74.
Cappello S, Böhringer CR, Bergami M, Conzelmann KK, Ghanem A, Tomassy GS, Arlotta P, Mainardi M, Allegra M, Caleo M, van Hengel J, Brakebusch C and Götz M. (2012) A radial glia-specific role of RhoA in double cortex formation. Neuron 73(5): 911-24.
Marschalek A, Drechsel L and Conzelmann KK. (2011) The importance of being short: The role of rabies virus phosphoprotein isoforms assessed by differential IRES translation initiation. Eur J Cell Biol. Mar 11 2011.
Rieder M, Brzózka K, Pfaller CK, Cox JH, Stitz L and Conzelmann KK. (2011) Genetic dissection of interferon-antagonistic functions of rabies virus phosphoprotein: inhibition of interferon regulatory factor 3 activation is important for pathogenicity. J Virol. 85(2): 842-52.
Cui S, Eisenächer K, Kirchhofer A, Brzózka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A and Hopfner KP. (2008) The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol Cell. 29(2): 169-79.
Hornung V, Ellegast J, Kim S, Brzózka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G. (2006) 5'-Triphosphate RNA is the ligand for RIG-I. Science 314(5801): 994-7.